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Proteintech 1 ap anti mouse acvr1 proteintech
1 Ap Anti Mouse Acvr1 Proteintech, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 11 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+mouse+acvr1/ACVR1+Antibody/pm40890486-233-116-119
Average 93 stars, based on 11 article reviews

1 ap anti mouse acvr1 proteintech - by Bioz Stars, 2026-10

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( A ) Schematic diagram depicting the generation of Acvr1 R206H/+ flox mice using CRISPR-Cas9 technology. ( B ) microCT showing spontaneous HO formation around the joints of Prrx1-Cre ; Acvr1 R206H/+ mice, but not Prrx1-Cre mice. ( C , D ) Representative microCT image ( C ) and statistical analysis ( D ) of HO formation in the tibial muscle of Tek -Cre ; Acvr1 R206H/+ mice, but not Tek -Cre mice after CTX injury ( n = 4 per group). **** P = 6.05e-7. ( E , F ) Representative HE staining ( E) and safranine O staining ( F ) images of the injured tendon of Gli1-CreER T2 and Gli1-CreER T2 ; Acvr1 R206H/+ mice at 7 dpi. Scale bar, 200 μm. ( G ) Statistical analysis of Safranine O + region in injured tendon of Gli1-CreER T2 and Gli1-CreER T2 ; Acvr1 R206H/+ mice at 7 dpi ( n = 5 per group). **** P = 2.28e-6. ( H ) Statistical analysis of HO volume in the injured tendon of Gli1-CreER T2 and Gli1-CreER T2 ; Acvr1 R206H/+ mice at 56 dpi ( n = 5 per group). **** P = 1.29e-5. ( I ) Representative microCT images of HO in the injured tendon of Gli1-CreER T2 and Gli1-CreER T2 ; Acvr1 R206H/+ mice at 56 dpi. ( J , K ) Statistical analysis ( J ) and representative immunofluorescence images ( K ) of Gli1 + cells in the injured tendon of Gli1-CreER T2 ; Ai9 and Gli1-CreER T2 ; Ai9; Acvr1 R206H/+ mice at 3, 5, and 7 dpi ( n = 5 per group). * P = 3.86e-2, ** P = 3.82e-3, **** P = 2.73e-4. Scale bar, 100 μm. Data are represented as the mean ± SD. All P values were determined by unpaired Student’s t test.

Journal: The EMBO Journal

Article Title: GNAS/PKA signaling promotes aberrant osteochondral differentiation of Gli1 + tendon sheath progenitors

doi: 10.1038/s44318-025-00553-7

Figure Lengend Snippet: ( A ) Schematic diagram depicting the generation of Acvr1 R206H/+ flox mice using CRISPR-Cas9 technology. ( B ) microCT showing spontaneous HO formation around the joints of Prrx1-Cre ; Acvr1 R206H/+ mice, but not Prrx1-Cre mice. ( C , D ) Representative microCT image ( C ) and statistical analysis ( D ) of HO formation in the tibial muscle of Tek -Cre ; Acvr1 R206H/+ mice, but not Tek -Cre mice after CTX injury ( n = 4 per group). **** P = 6.05e-7. ( E , F ) Representative HE staining ( E) and safranine O staining ( F ) images of the injured tendon of Gli1-CreER T2 and Gli1-CreER T2 ; Acvr1 R206H/+ mice at 7 dpi. Scale bar, 200 μm. ( G ) Statistical analysis of Safranine O + region in injured tendon of Gli1-CreER T2 and Gli1-CreER T2 ; Acvr1 R206H/+ mice at 7 dpi ( n = 5 per group). **** P = 2.28e-6. ( H ) Statistical analysis of HO volume in the injured tendon of Gli1-CreER T2 and Gli1-CreER T2 ; Acvr1 R206H/+ mice at 56 dpi ( n = 5 per group). **** P = 1.29e-5. ( I ) Representative microCT images of HO in the injured tendon of Gli1-CreER T2 and Gli1-CreER T2 ; Acvr1 R206H/+ mice at 56 dpi. ( J , K ) Statistical analysis ( J ) and representative immunofluorescence images ( K ) of Gli1 + cells in the injured tendon of Gli1-CreER T2 ; Ai9 and Gli1-CreER T2 ; Ai9; Acvr1 R206H/+ mice at 3, 5, and 7 dpi ( n = 5 per group). * P = 3.86e-2, ** P = 3.82e-3, **** P = 2.73e-4. Scale bar, 100 μm. Data are represented as the mean ± SD. All P values were determined by unpaired Student’s t test.

Article Snippet: Anti-mouse ACVR1 , Proteintech , Cat#67417-1-Ig.

Techniques: CRISPR, Staining, Immunofluorescence

( A , B ) Representative immunofluorescence and statistical analysis of GLI1 and ACVR1 in injured site of Gli1-CreER T2 ; Ai9 and Gli1-CreER T2 ; Ai9; Acvr1 R206H/+ mice at 5 dpi ( n = 5 per group). P = 5.18e-1. N.S. indicated no significance. Scale bar, 100:μm. ( C , D ) Representative immunofluorescence and statistical analysis of GLI1 and p-SMAD1/5 in injured site of Gli1-CreER T2 ; Ai9 and Gli1-CreER T2 ; Ai9; Acvr1 R206H/+ mice at 5 dpi ( n = 5 per group). **** P = 6.89e-6. Scale bar, 100 μm. ( E ) Sanger sequencing showed that the STOP cassette preceding the Acvr1 R206H/+ mutation was disrupted. Data is presented as mean ± SD. All P values were determined by unpaired Student’s t test.

Journal: The EMBO Journal

Article Title: GNAS/PKA signaling promotes aberrant osteochondral differentiation of Gli1 + tendon sheath progenitors

doi: 10.1038/s44318-025-00553-7

Figure Lengend Snippet: ( A , B ) Representative immunofluorescence and statistical analysis of GLI1 and ACVR1 in injured site of Gli1-CreER T2 ; Ai9 and Gli1-CreER T2 ; Ai9; Acvr1 R206H/+ mice at 5 dpi ( n = 5 per group). P = 5.18e-1. N.S. indicated no significance. Scale bar, 100:μm. ( C , D ) Representative immunofluorescence and statistical analysis of GLI1 and p-SMAD1/5 in injured site of Gli1-CreER T2 ; Ai9 and Gli1-CreER T2 ; Ai9; Acvr1 R206H/+ mice at 5 dpi ( n = 5 per group). **** P = 6.89e-6. Scale bar, 100 μm. ( E ) Sanger sequencing showed that the STOP cassette preceding the Acvr1 R206H/+ mutation was disrupted. Data is presented as mean ± SD. All P values were determined by unpaired Student’s t test.

Article Snippet: Anti-mouse ACVR1 , Proteintech , Cat#67417-1-Ig.

Techniques: Immunofluorescence, Sequencing, Mutagenesis

( A , B ) Representative immunofluorescence images ( A ) and statistical analysis of frequency ( B ) of GLI1 - / FMOD - , GLI1 + / FMOD - , GLI1 + / FMOD + , GLI1 - / FMOD + cells in the injured site of FOP model mice at 3 dpi ( n = 5 per group). P values from left to right: ** P = 2.27e-3, **** P = 1.17e-12, *** P = 4.59e-4, **** P = 6.94e-13, **** P = 2.49e-11. Scale bar, 200 or 20 μm. ( C, D ) Representative immunofluorescence images ( C ) and statistical analysis of frequency ( D ) of GLI1 - / SOX9 - , GLI1 + /SOX9 − , GLI1 − /SOX9 + , GLI1 + / SOX9 + cells in the injured site of FOP model mice at 5 dpi ( n = 5 per group). P values from left to right: * P = 2.52e-2, * P = 1.85e-2, **** P = 3.43e-5, *** P = 4.18e-4. Scale bar, 200 or 20 μm. ( E , F ) Representative immunofluorescence images ( E ) and statistical analysis of frequency ( F ) of GLI1 − /RUNX2 - , GLI1 + /RUNX2 − , GLI1 − /RUNX2 + , GLI1 + /RUNX2 + cells in the injured site of FOP model mice at 5 dpi ( n = 5 per group). P values from left to right: **** P = 5.56e-5, **** P = 1.32e-6, ** P = 1.12e-3, **** P = 1.73e-5. Scale bar, 200 or 20 μm. ( G , H ) Representative immunofluorescence images ( G ) and statistical analysis of frequency ( H ) of GLI1 - /COL2 - , GLI1 + / COL2 − , GLI1 + / COL2 + , GLI1 - / COL2 + cells in the injured site of FOP model mice at 7 dpi ( n = 5 per group). P values from left to right: **** P = 1.52e-10, **** P = 2.90e-11, **** P = 6.99e-11. Scale bar, 200 or 20 μm. ( I ) Representative immunofluorescence images showing Gli1 + tendon sheath progenitors differentiate into osteocytes at 14 dpi in FOP model mice. Scale bar, 200 or 20 μm. ( J ) Statistical analysis of the frequency of GLI1 - /OCN - , GLI1 + /OCN + , GLI1 - /OCN + , GLI1 + /OCN - cells in the injured site of FOP model mice at 14 dpi ( n = 5 per group). P values from left to right: **** P = 8.87e-11, **** P = 9.49e-7, **** P = 4.35e-10, **** P = 3.85e-6, **** P = 6.35e-5. ( K , L ) Representative Safranine O staining images ( K ) and statistical analysis ( L ) of chondrocyte region in the injured tendon of Gli1 - CreER T2 ; Acvr1 R206H/+ and Gli1 - CreER T2 ; Acvr1 R206H/+ ; DTA mice ( n = 5 per group). *** P = 3.27e-4. Scale bar, 200 μm. ( M , N ) Representative microCT images ( M ) and statistical analysis ( N ) of HO in the injured tendon of Gli1 - Cre ERT2 ; Acvr1 R206H/+ and Gli1 - Cre ERT2 ; Acvr1 R206H/+ ; DTA mice at 63 dpi ( n = 5 per group). **** P = 7.86e-7. Data are presented as mean ± SD. All P values were determined by One-way ANOVA with Bonferroni post hoc test ( B , D , F , H , J ) and unpaired Student’s t test ( L , N ).

Journal: The EMBO Journal

Article Title: GNAS/PKA signaling promotes aberrant osteochondral differentiation of Gli1 + tendon sheath progenitors

doi: 10.1038/s44318-025-00553-7

Figure Lengend Snippet: ( A , B ) Representative immunofluorescence images ( A ) and statistical analysis of frequency ( B ) of GLI1 - / FMOD - , GLI1 + / FMOD - , GLI1 + / FMOD + , GLI1 - / FMOD + cells in the injured site of FOP model mice at 3 dpi ( n = 5 per group). P values from left to right: ** P = 2.27e-3, **** P = 1.17e-12, *** P = 4.59e-4, **** P = 6.94e-13, **** P = 2.49e-11. Scale bar, 200 or 20 μm. ( C, D ) Representative immunofluorescence images ( C ) and statistical analysis of frequency ( D ) of GLI1 - / SOX9 - , GLI1 + /SOX9 − , GLI1 − /SOX9 + , GLI1 + / SOX9 + cells in the injured site of FOP model mice at 5 dpi ( n = 5 per group). P values from left to right: * P = 2.52e-2, * P = 1.85e-2, **** P = 3.43e-5, *** P = 4.18e-4. Scale bar, 200 or 20 μm. ( E , F ) Representative immunofluorescence images ( E ) and statistical analysis of frequency ( F ) of GLI1 − /RUNX2 - , GLI1 + /RUNX2 − , GLI1 − /RUNX2 + , GLI1 + /RUNX2 + cells in the injured site of FOP model mice at 5 dpi ( n = 5 per group). P values from left to right: **** P = 5.56e-5, **** P = 1.32e-6, ** P = 1.12e-3, **** P = 1.73e-5. Scale bar, 200 or 20 μm. ( G , H ) Representative immunofluorescence images ( G ) and statistical analysis of frequency ( H ) of GLI1 - /COL2 - , GLI1 + / COL2 − , GLI1 + / COL2 + , GLI1 - / COL2 + cells in the injured site of FOP model mice at 7 dpi ( n = 5 per group). P values from left to right: **** P = 1.52e-10, **** P = 2.90e-11, **** P = 6.99e-11. Scale bar, 200 or 20 μm. ( I ) Representative immunofluorescence images showing Gli1 + tendon sheath progenitors differentiate into osteocytes at 14 dpi in FOP model mice. Scale bar, 200 or 20 μm. ( J ) Statistical analysis of the frequency of GLI1 - /OCN - , GLI1 + /OCN + , GLI1 - /OCN + , GLI1 + /OCN - cells in the injured site of FOP model mice at 14 dpi ( n = 5 per group). P values from left to right: **** P = 8.87e-11, **** P = 9.49e-7, **** P = 4.35e-10, **** P = 3.85e-6, **** P = 6.35e-5. ( K , L ) Representative Safranine O staining images ( K ) and statistical analysis ( L ) of chondrocyte region in the injured tendon of Gli1 - CreER T2 ; Acvr1 R206H/+ and Gli1 - CreER T2 ; Acvr1 R206H/+ ; DTA mice ( n = 5 per group). *** P = 3.27e-4. Scale bar, 200 μm. ( M , N ) Representative microCT images ( M ) and statistical analysis ( N ) of HO in the injured tendon of Gli1 - Cre ERT2 ; Acvr1 R206H/+ and Gli1 - Cre ERT2 ; Acvr1 R206H/+ ; DTA mice at 63 dpi ( n = 5 per group). **** P = 7.86e-7. Data are presented as mean ± SD. All P values were determined by One-way ANOVA with Bonferroni post hoc test ( B , D , F , H , J ) and unpaired Student’s t test ( L , N ).

Article Snippet: Anti-mouse ACVR1 , Proteintech , Cat#67417-1-Ig.

Techniques: Immunofluorescence, Staining

( A – D ) Representative immunofluorescence images of GNAS expression in uninjured tendons ( A ) and injured sites of Gli1 - CreER T2 ; Ai9 mice at 5 ( B ), 7 ( C ) and 14 ( D ) dpi. Scale bar, 50 μm. ( E , F ) Statistical analysis of GNAS + region ( E ) and GNAS + /GLI1 + region ( F ) in uninjured tendons and injured sites of Gli1 - CreER T2 ; Acvr1 R206H/+ mice at 5, 7 and 14 dpi ( n = 5 per group). P values from left to right: **** P = 8.29e-10, **** P = 1.16e-8, **** P = 1.57e-8. **** P = 2.36e-9, **** P = 1.71e-6, **** P = 9.06e-6. ( G , H ) Statistical analysis of p-PKA substrate + region ( G ) and p-PKA substrate + /GLI1 + region ( H ) in uninjured tendons and injured sites of Gli1 - CreER T2 ; Acvr1 R206H/+ mice at 5, 7 and 14 dpi ( n = 5 per group). P values from left to right: **** P = 1.42e-6, **** P = 7.23e-6, **** P = 1.53e-5. **** P = 1.96e-5, ** P = 2.63e-3, **** P = 6.44e-4. ( I – L ) Representative immunofluorescence images of p-PKA substrate expression in uninjured tendons ( I ) and injured sites of Gli1 - CreER T2 ; Acvr1 R206H/+ mice at 5 ( J ), 7 ( K ) and 14 ( L ) dpi. Scale bar, 50 μm. Data is presented as mean ± SD. All P values were determined by unpaired Student’s t test.

Journal: The EMBO Journal

Article Title: GNAS/PKA signaling promotes aberrant osteochondral differentiation of Gli1 + tendon sheath progenitors

doi: 10.1038/s44318-025-00553-7

Figure Lengend Snippet: ( A – D ) Representative immunofluorescence images of GNAS expression in uninjured tendons ( A ) and injured sites of Gli1 - CreER T2 ; Ai9 mice at 5 ( B ), 7 ( C ) and 14 ( D ) dpi. Scale bar, 50 μm. ( E , F ) Statistical analysis of GNAS + region ( E ) and GNAS + /GLI1 + region ( F ) in uninjured tendons and injured sites of Gli1 - CreER T2 ; Acvr1 R206H/+ mice at 5, 7 and 14 dpi ( n = 5 per group). P values from left to right: **** P = 8.29e-10, **** P = 1.16e-8, **** P = 1.57e-8. **** P = 2.36e-9, **** P = 1.71e-6, **** P = 9.06e-6. ( G , H ) Statistical analysis of p-PKA substrate + region ( G ) and p-PKA substrate + /GLI1 + region ( H ) in uninjured tendons and injured sites of Gli1 - CreER T2 ; Acvr1 R206H/+ mice at 5, 7 and 14 dpi ( n = 5 per group). P values from left to right: **** P = 1.42e-6, **** P = 7.23e-6, **** P = 1.53e-5. **** P = 1.96e-5, ** P = 2.63e-3, **** P = 6.44e-4. ( I – L ) Representative immunofluorescence images of p-PKA substrate expression in uninjured tendons ( I ) and injured sites of Gli1 - CreER T2 ; Acvr1 R206H/+ mice at 5 ( J ), 7 ( K ) and 14 ( L ) dpi. Scale bar, 50 μm. Data is presented as mean ± SD. All P values were determined by unpaired Student’s t test.

Article Snippet: Anti-mouse ACVR1 , Proteintech , Cat#67417-1-Ig.

Techniques: Immunofluorescence, Expressing

( A , B ) Representative immunofluorescence images ( A ) and statistical analysis ( B ) of SOX9 + region in injured site from tenotomized mice following vehicle and NF449 treatment ( n = 5 per group). *** P = 8.94e-4. Scale bar, 10 μm. ( C , D ) Representative immunofluorescence images ( C ) and statistical analysis ( D ) of RUNX2 + region in injured site from tenotomized mice following vehicle and NF449 treatment ( n = 5 per group). * P = 1.37e-2. Scale bar, 10 μm. ( E , F ) Representative Safranine O staining images ( E ) and statistical analysis ( F ) of Safranine O + region in injured site from tenotomized mice following vehicle and NF449 treatment ( n = 5 per group). ** P = 1.85e-3. Scale bar, 100 μm. ( G , H ) Representative microCT images ( G ) and statistical analysis ( H ) of HO volume in injured site from tenotomized mice following vehicle and NF449 treatment ( n = 5 per group). *** P = 1.39e-4. ( I , J ) Representative Safranine O staining images ( I ) and statistical analysis ( J ) of Safranine O + region in injured site from tenotomized Gli1-CreER T2 and Gli1-CreER T2 ; Prkaca f/f mice ( n = 5 per group). *** P = 1.18e-4. Scale bar, 100 μm. ( K , L ) Representative microCT images ( K ) and statistical analysis ( L ) of HO volume in injured site from tenotomized Gli1-CreER T2 and Gli1-CreER T2 ; Prkaca f/f mice ( n = 5 per group). *** P = 5.11e-4. ( M , N ) Representative Safranine O staining images ( M ) and statistical analysis ( N ) of Safranine O + region in injured site from tenotomized Gli1-CreER T2 ; Acvr1 R206H/+ mice following vehicle and NF449 treatment ( n = 5 per group). **** P = 1.5e-7. Scale bar, 100 μm. ( O , P ) Representative microCT images ( O ) and statistical analysis ( P ) of HO volume in injured site from tenotomized Gli1-CreER T2 ; Acvr1 R206H/+ mice following vehicle and NF449 treatment ( n = 5 per group). **** P = 3.87e-6. ( Q , R ) Representative Safranine O staining images ( Q ) and statistical analysis ( R ) of Safranine O + region in injured site from tenotomized Gli1-CreER T2 ; Acvr1 R206H/+ and Gli1-CreER T2 ; Acvr1 R206H/+ ; Prkaca f/f mice at 7 dpi ( n = 5 per group). **** P = 6.2e-7. Scale bar, 100 μm. ( S , T ) Representative microCT images ( S ) and statistical analysis ( T ) of HO volume in injured site from tenotomized Gli1-CreER T2 ; Acvr1 R206H/+ and Gli1-CreER T2 ; Acvr1 R206H/+ ; Prkaca f/f mice at 14 dpi ( n = 5 per group). *** P = 1.79e-4. Data are presented as mean ± SD. All P values were determined by unpaired Student’s t test.

Journal: The EMBO Journal

Article Title: GNAS/PKA signaling promotes aberrant osteochondral differentiation of Gli1 + tendon sheath progenitors

doi: 10.1038/s44318-025-00553-7

Figure Lengend Snippet: ( A , B ) Representative immunofluorescence images ( A ) and statistical analysis ( B ) of SOX9 + region in injured site from tenotomized mice following vehicle and NF449 treatment ( n = 5 per group). *** P = 8.94e-4. Scale bar, 10 μm. ( C , D ) Representative immunofluorescence images ( C ) and statistical analysis ( D ) of RUNX2 + region in injured site from tenotomized mice following vehicle and NF449 treatment ( n = 5 per group). * P = 1.37e-2. Scale bar, 10 μm. ( E , F ) Representative Safranine O staining images ( E ) and statistical analysis ( F ) of Safranine O + region in injured site from tenotomized mice following vehicle and NF449 treatment ( n = 5 per group). ** P = 1.85e-3. Scale bar, 100 μm. ( G , H ) Representative microCT images ( G ) and statistical analysis ( H ) of HO volume in injured site from tenotomized mice following vehicle and NF449 treatment ( n = 5 per group). *** P = 1.39e-4. ( I , J ) Representative Safranine O staining images ( I ) and statistical analysis ( J ) of Safranine O + region in injured site from tenotomized Gli1-CreER T2 and Gli1-CreER T2 ; Prkaca f/f mice ( n = 5 per group). *** P = 1.18e-4. Scale bar, 100 μm. ( K , L ) Representative microCT images ( K ) and statistical analysis ( L ) of HO volume in injured site from tenotomized Gli1-CreER T2 and Gli1-CreER T2 ; Prkaca f/f mice ( n = 5 per group). *** P = 5.11e-4. ( M , N ) Representative Safranine O staining images ( M ) and statistical analysis ( N ) of Safranine O + region in injured site from tenotomized Gli1-CreER T2 ; Acvr1 R206H/+ mice following vehicle and NF449 treatment ( n = 5 per group). **** P = 1.5e-7. Scale bar, 100 μm. ( O , P ) Representative microCT images ( O ) and statistical analysis ( P ) of HO volume in injured site from tenotomized Gli1-CreER T2 ; Acvr1 R206H/+ mice following vehicle and NF449 treatment ( n = 5 per group). **** P = 3.87e-6. ( Q , R ) Representative Safranine O staining images ( Q ) and statistical analysis ( R ) of Safranine O + region in injured site from tenotomized Gli1-CreER T2 ; Acvr1 R206H/+ and Gli1-CreER T2 ; Acvr1 R206H/+ ; Prkaca f/f mice at 7 dpi ( n = 5 per group). **** P = 6.2e-7. Scale bar, 100 μm. ( S , T ) Representative microCT images ( S ) and statistical analysis ( T ) of HO volume in injured site from tenotomized Gli1-CreER T2 ; Acvr1 R206H/+ and Gli1-CreER T2 ; Acvr1 R206H/+ ; Prkaca f/f mice at 14 dpi ( n = 5 per group). *** P = 1.79e-4. Data are presented as mean ± SD. All P values were determined by unpaired Student’s t test.

Article Snippet: Anti-mouse ACVR1 , Proteintech , Cat#67417-1-Ig.

Techniques: Immunofluorescence, Staining

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